Article

Curating MitoCore: A Standardized Small-Scale Human Metabolic Model as Platform for Proteomics Integration and Disease Modeling

2026-06-29

Abstract excerpt

<h4>Motivation</h4> Central human metabolism powers cellular processes, yet its dysregulation in disease remains poorly understood. While comprehensive genome-scale metabolic models like Human-GEM are available, their size limits interpretability and computational efficiency. Conversely, the smaller MitoCore model is more manageable but lacks the standardized annotations and curated gene-protein-reaction (GPR) as...

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Literature Corpus work: 1db253e9-f6b6-5ffe-a478-96d1d99045a1
DOI: 10.64898/2026.06.29.734258

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