Article

Constraint-based modeling predicts metabolic signatures of low- and high-grade serous ovarian cancer

2023-03-12

Abstract excerpt

Ovarian cancer is an aggressive, heterogeneous disease, burdened with late diagnosis and resistance to chemotherapy. Clinical features of ovarian cancer could be explained by investigating its metabolism, and how the regulation of specific pathways link to individual phenotypes. Ovarian cancer is of particular interest for metabolic research due to its heterogeneous nature, with five distinct subtypes having been...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dfaca6d2-274d-573d-a37b-204f51133540
DOI: 10.1101/2023.03.09.531870

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Constraint-based modeling predicts metabolic signatures of low- and high-grade serous ovarian cancerDOI 10.1101/2023.03.09.531870Read

Transcriptome-Driven Constraint-Based Modelling Reveals Metabolic Targets for Ovarian CancerSemantic proximity Read

Multi-omics-driven kinetic modeling reveals metabolic adaptations and vulnerabilities in BRCA1-deficient ovarian cancerSemantic proximity Read

Targeting metabolic fluxes reverts metastatic transitions in ovarian cancerSemantic proximity Read

A Single-Cell Network Approach to Decode Metabolic Regulation in Gynecologic and Breast CancersSemantic proximity Read

A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scale.Semantic proximity Read

Human Genome-Scale Models of Metabolism and Gene Expression Reveal Resource Constraints of Cancer Cell LinesSemantic proximity Read

A pipeline for the reconstruction and evaluation of context-specific human metabolic models at a large-scaleSemantic proximity Read

A new genome-scale model enables prediction of cancer metabolic dependenciesSemantic proximity Read

Development of molecular subtype and prognostic model related to metabolism-related genes in high-grade serous ovarian cancer: A study based on ten cohortsSemantic proximity Read

Modeling core metabolism in cancer cells: surveying the topology underlying the Warburg effect.Semantic proximity Read

INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulationSemantic proximity Read

Identification and validation of a prognostic index based on a metabolic-genomic landscape analysis of ovarian cancerSemantic proximity Read