Article
An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program.
Scientific reports - 30 Oct 2017
Tasseff Ryan, Jensen Holly A, Congleton Johanna, Dai David, Rogers Katharine V, Sagar Adithya, Bunaciu Rodica P, Yen Andrew, Varner Jeffrey D
Abstract excerpt
In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced differentiation of HL-60 cells. The model describes reinforcing feedback between an ATRA-inducible signalsome complex involving many proteins including Vav1, a guanine nucleotide exchange factor, and the activation of the mitogen activated protein kinase (MAPK) cascade. We decomposed the effective model into three modules; a...
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