Article

Gene regulatory logic of the interferon-β enhancer contains multiple selectively deployed modes of transcription factor synergy

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Type I interferon IFNβ is a key regulator of the immune response, and its dysregulated expression causes disease. The regulation of IFNβ promoter activity has been a touchpoint of mammalian gene control research since the discovery of functional synergy between two stimulus-responsive transcription factors (TFs) nuclear factor kappa B (NFκB) and interferon regulatory factors (IRF). However, subs...

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Literature Corpus work: 1dc6fd58-4881-5b0c-bd87-681f84000248
DOI: 10.1101/2025.02.04.636520

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