Article
Molecular circuits, biological switches, and nonlinear dose-response relationships.
Environmental health perspectives - 1 Dec 2002
Andersen Melvin E, Yang Raymond S H, French C Tenley, Chubb Laura S, Dennison James E
Abstract excerpt
Signaling motifs (nuclear transcriptional receptors, kinase/phosphatase cascades, G-coupled protein receptors, etc.) have composite dose-response behaviors in relation to concentrations of protein receptors and endogenous signaling molecules. "Molecular circuits" include the biological components and their interactions that comprise the workings of these signaling motifs. Many of these molecular circuits have...
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