Article

<i>Cancer Cachexia in STK11/LKB1</i> -mutated NSCLC is Dependent on Tumor-secreted GDF15

2024-06-17

Abstract excerpt

<h4>ABSTRACT</h4> Cachexia is a wasting syndrome comprised of adipose, muscle, and weight loss observed in cancer patients. Tumor loss-of-function mutations in STK11/LKB1 , a regulator of the energy sensor AMP-activated protein kinase, induce cancer cachexia (CC) in preclinical models and are associated with cancer-related weight loss in NSCLC patients. Here we characterized the relevance of the NSCLC-associated...

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Literature Corpus work: be78f7ff-34cc-5dcd-9e3f-3189cb36ea6c
DOI: 10.1101/2024.06.14.598891

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