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Article

Caloric restriction and metformin selectively improved LKB1-mutated NSCLC tumor response to chemo- and chemo-immunotherapy.

Journal of experimental & clinical cancer research : CR - 2 Jan 2024

Ndembe Gloriana, Intini Ilenia, Moro Massimo, Grasselli Chiara, Panfili Andrea, Panini Nicolò, Bleve Augusto, Occhipinti Mario, Borzi Cristina, Garassino Marina Chiara, Marabese Mirko, Canesi Simone, Scanziani Eugenio, Sozzi Gabriella, Broggini Massimo, Ganzinelli Monica

Abstract excerpt

BACKGROUND: About 10% of NSCLCs are mutated in KRAS and impaired in STK11/LKB1, a genetic background associated with poor prognosis, caused by an increase in metastatic burden and resistance to standard therapy. LKB1 is a protein involved in a number of biological processes and is particularly important for its role in the regulation of cell metabolism. LKB1 alterations lead to protein loss that causes...

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Identifiers

PMID: 38163906
DOI: 10.1186/s13046-023-02933-5
PMCID: PMC10759660

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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