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Article

Cancer cachexia in STK11/LKB1-mutated non-small cell lung cancer is dependent on tumor-secreted GDF15.

Nature communications - 30 Jan 2026

Yu Jinhai, Guo Tong, Gupta Arun, Llano Ernesto M, Salisbury Thomas, Wajahat Naureen, Zhao Dianne, Slater Sean, Deng Qing, Akbay Esra A, Rothermel Beverly A, Shelton John M, Evers Bret M, Wu Zhidan, Tzameli Iphigenia, Pashos Evanthia, Kim James, Minna John D, Iyengar Puneeth, Infante Rodney E

Abstract excerpt

Cachexia is a wasting syndrome involving adipose, muscle, and body weight loss in cancer patients. Tumor loss-of-function mutations in STK11/LKB1, a regulator of AMP-activated protein kinase, induce cancer cachexia (CC) in preclinical models and are linked to weight loss in non-small cell lung cancer (NSCLC) patients. This study examines the role of the integrated stress response (ISR) cytokine growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41617691
DOI: 10.1038/s41467-026-68702-y
PMCID: PMC12960653

Genes

GDF15
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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