Article
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia.
JCI insight - 24 Apr 2023
Iyengar Puneeth, Gandhi Aakash Y, Granados Jorge, Guo Tong, Gupta Arun, Yu Jinhai, Llano Ernesto M, Zhang Faya, Gao Ang, Kandathil Asha, Williams Dorothy, Gao Boning, Girard Luc, Malladi Venkat S, Shelton John M, Evers Bret M, Hannan Raquibul, Ahn Chul, Minna John D, Infante Rodney E
Abstract excerpt
Cancer cachexia (CC), a wasting syndrome of muscle and adipose tissue resulting in weight loss, is observed in 50% of patients with solid tumors. Management of CC is limited by the absence of biomarkers and knowledge of molecules that drive its phenotype. To identify such molecules, we injected 54 human non-small cell lung cancer (NSCLC) lines into immunodeficient mice, 17 of which produced an unambiguous...
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