Article
Collagen-producing lung cell atlas identifies multiple subsets with distinct localization and relevance to fibrosis.
Nature communications - 21 Apr 2020
Tsukui Tatsuya, Sun Kai-Hui, Wetter Joseph B, Wilson-Kanamori John R, Hazelwood Lisa A, Henderson Neil C, Adams Taylor S, Schupp Jonas C, Poli Sergio D, Rosas Ivan O, Kaminski Naftali, Matthay Michael A, Wolters Paul J, Sheppard Dean
Abstract excerpt
Collagen-producing cells maintain the complex architecture of the lung and drive pathologic scarring in pulmonary fibrosis. Here we perform single-cell RNA-sequencing to identify all collagen-producing cells in normal and fibrotic lungs. We characterize multiple collagen-producing subpopulations with distinct anatomical localizations in different compartments of murine lungs. One subpopulation, characterized by...
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