Article

Heterologous Expression of Human Norovirus GII.4 VP1 Leads to Assembly of T=4 Virus-Like Particles

2019-03-21

Abstract excerpt

<h4>ABSTRACT</h4> Human noroviruses are a leading cause of acute gastroenteritis, yet there are still no vaccines or antivirals available. Expression of the norovirus capsid protein (VP1) in insect cells typically results in the formation of virus-like particles (VLPs) that are morphologically and antigenically comparable to native virions. Previous structural analysis of norovirus VLPs showed that the capsid has...

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Literature Corpus work: be43b53a-44e4-5d3c-9e0f-89cf52779e8a
DOI: 10.1101/583385

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