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Article

Mutational analysis of human norovirus VP2 elucidates critical molecular interactions for virus assembly.

Journal of virology - 17 Feb 2026

Dave Janam J, Crawford Sue E, Atmar Robert L, Ettayebi Khalil, Prasad B V Venkataram, Estes Mary K

Abstract excerpt

Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis, with ≥80% of infections caused by the GII genogroup. HuNoVs are non-enveloped, with an icosahedral capsid composed of 90 dimers of the major capsid protein VP1, which encloses a minor structural protein, VP2, and a VPg-linked, positive-sense ssRNA genome. Although the atomic structure of the icosahedral capsid formed by VP1 is well...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41468551
DOI: 10.1128/jvi.01420-25
PMCID: PMC12911861

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