Article

Mutational Analysis of Human Norovirus VP2 Elucidates Critical Molecular Interactions for Virus Assembly

2025-08-23

Abstract excerpt

Human noroviruses ( HuNoV s) are the leading cause of viral gastroenteritis with ≥80% of infections caused by the GII genogroup. HuNoVs are non-enveloped, with an icosahedral capsid composed of 90 dimers of the major capsid protein VP1, which encloses a minor structural protein, VP2, and a VPg-linked positive sense ssRNA genome. Although the atomic structure of the icosahedral capsid formed by VP1 is well charact...

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Literature Corpus work: 5932d888-e5d9-5865-8555-0082397558f4
DOI: 10.1101/2025.08.23.671901

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