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Article

Structural heterogeneity of a human norovirus vaccine candidate

28 Oct 2020

Abstract excerpt

Human norovirus virus-like particles (VLPs) are assumed to be morphologically and antigenically similar to virion particles. The norovirus virion is assembled from 180 copies of the capsid protein (VP1) and exhibits T = 3 icosahedral symmetry. In this study, we showed that the vaccine candidate GII.4c VP1 formed T = 1 and T = 3 VLPs, but mainly assembled into T = 4 icosahedral particles that were composed of 240...

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Identifiers

PMID: 33202318
DOI: 10.1016/j.virol.2020.10.005

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