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Sequence addition to the N- or C-terminus of the major capsid protein VP1 of norovirus affects its cleavage and assembly into virus-like particles.

Microbial pathogenesis - 1 Aug 2022

Ma Jie, Liu Jinjin, Zheng Lijun, Wang Chao, Zhao Qingxia, Huo Yuqi

Abstract excerpt

Norovirus (NoV) infection is a leading cause of non-bacterial gastroenteritis worldwide and there are currently no effective therapeutics available to target the virus. The norovirus major capsid protein VP1 is a potential candidate for the development of vaccines due to the similar morphology and immunogenicity of its assembled virus-like particles (VLPs) compared to native virions. In this study, we explored...

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Caliciviridae Infections
Capsid Proteins
Gastroenteritis
Genotype
Norovirus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Binding

Recombinant Proteins

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PMID: 35700875
DOI: 10.1016/j.micpath.2022.105633

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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