Article
'There and back again': revisiting the pathophysiological roles of human endogenous retroviruses in the post-genomic era.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 19 Sept 2013
Magiorkinis Gkikas, Belshaw Robert, Katzourakis Aris
Abstract excerpt
Almost 8% of the human genome comprises endogenous retroviruses (ERVs). While they have been shown to cause specific pathologies in animals, such as cancer, their association with disease in humans remains controversial. The limited evidence is partly due to the physical and bioethical restrictions surrounding the study of transposons in humans, coupled with the major experimental and bioinformatics challenges...
Topics
- DNA Transposable Elements
- Endogenous Retroviruses
- Gene Expression Regulation, Viral
- Genome, Human
- Humans
- Mutation
- Neoplasms