Article

Opposing immune and genetic forces shape oncogenic programs in synovial sarcoma

2019-08-04

Abstract excerpt

<h4>ABSTRACT</h4> Synovial sarcoma is an aggressive mesenchymal neoplasm, driven by the SS18-SSX fusion, and characterized by immunogenic antigens expression and exceptionally low T cell infiltration levels. To study the cancer-immune interplay in this disease, we profiled 16,872 cells from 12 human synovial sarcoma tumors using single-cell RNA-sequencing (scRNA-Seq). Synovial sarcoma manifests antitumor immunity...

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Literature Corpus work: a36d6804-8299-5513-bc17-2ee1602396c2
DOI: 10.1101/724302

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