Endogenous Retroviruses as Modulators of Innate Immunity

doi:10.3390/pathogens12020162

Article

Endogenous Retroviruses as Modulators of Innate Immunity

19 Jan 2023

Abstract excerpt

Endogenous retroviruses (ERVs), or LTR retrotransposons, are a class of transposable elements that are highly represented in mammalian genomes. Human ERVs (HERVs) make up roughly 8.3% of the genome and over the course of evolution, HERV elements underwent positive selection and accrued mutations that rendered them non-infectious; thereby, the genome could co-opt them into constructive roles with important...

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