Article
PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
2019-06-27
Abstract excerpt
Polycomb repressive complex 2 (PRC2) is a chromatin binding complex that represses gene expression by methylating histone H3 at K27 to establish repressed chromatin domains. PRC2 can either regulate genes directly through the methyltransferase activity of its component EZH2 or indirectly by regulating other gene regulators. Gene expression analysis of glioblastoma (GBM) cells lacking EZH2 showed that PRC2 regulate...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- be3c540d-15a7-5d87-9b77-96bda178ea39
- DOI
- 10.1101/681858