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Article

MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells

3 Jun 2013

Abstract excerpt

BACKGROUND: The Polycomb Repressor Complex (PRC) is an epigenetic regulator of transcription whose action is mediated by 2 protein complexes, PRC1 and PRC2. PRC is oncogenic in glioblastoma, where it is involved in cancer stem cell maintenance and radioresistance. METHODS: We used a set of glioblastoma patient samples, glioma stem cells, and neural stem cells from a mouse model of glioblastoma. We characterized...

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PMID: 23733246
DOI: 10.1093/neuonc/not055

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