Article

Overexpression of EZH2 is associated with clinicopathological parameters and poor prognosis in gliomas

2024-04-30

Abstract excerpt

<title>Abstract</title> <p>Histone methyltransferase EZH2, primarily localized in the nucleus, mediates constitutive Polycomb repressive complex activity by trimethylating lysine 27 of histone H3 (H3K27me3), leading to gene silencing through canonical and noncanonical mechanisms, resulting in transcriptional repression or activation. Its involvement is crucial in cell growth, proliferation, differentiation, and a...

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Literature Corpus work: 7a6e0676-557b-549d-b521-80b5a965c6c4
DOI: 10.21203/rs.3.rs-4247939/v1

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