Article

Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal Strength

2021-03-02

Abstract excerpt

<h4>Summary</h4> How T cell receptor (TCR) signal strength modulates T cell function and to what extent this is modified by immune checkpoint blockade (ICB) are key questions in immunology. Using Nr4a3-Tocky mice as a digital read-out of NFAT pathway activity, we identify the rapid quantitative and qualitative changes that occur in CD4 + T cells in response to a range of TCR signalling strengths. We demonstrate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be2f36c4-7ccb-53ab-8ff6-17ccc154d155
DOI: 10.1101/2021.03.02.431957

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Antigen and Checkpoint Receptor Recalibration of T Cell Receptor Signal StrengthDOI 10.1101/2021.03.02.431957Read

Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strengthSemantic proximity Read

Signalome-wide mapping of the NFκB pathway in T-cells reveals novel targets for immunotherapySemantic proximity Read

Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeqSemantic proximity Read

Exhausted T cell phenotypes depend on TCR signal strength.Semantic proximity Read

Precise engineering of chimeric antigen receptor expression levels defines T cell identity and functionSemantic proximity Read

Naïve arthritogenic SKG T cells have a defect in anergy and a repertoire pruned by superantigenSemantic proximity Read

Activation of the Tec Kinase ITK Controls Graded IRF4 Expression in Response to Variations in TCR Signal StrengthSemantic proximity Read

Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice.Semantic proximity Read

Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8 <sup>⁺</sup> T cell reprogrammingSemantic proximity Read

Control of T Cell Function by Positive and Negative RegulatorsSemantic proximity Read

Differential impact of TNFRSF co-stimulation on CD8 <sup>+</sup> T cell cytokine production by feedback control of surface receptor expressionSemantic proximity Read

NFAT and NF-κB dynamically co-regulate TCR and CAR signaling responses in human T cellsSemantic proximity Read