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Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8 <sup>⁺</sup> T cell reprogramming

2026-04-10

Abstract excerpt

Most oncolytic viruses are delivered by intratumoural injection, and local administration can induce regression of both injected and distant tumours in mice and patients. However, the mechanisms by which local viral infection reprograms systemic immunity remain poorly understood. Here we show that intratumoural RP1, an oncolytic HSV-1 encoding GM-CSF and GALV-GP-R ⁻ , drives regression of injected and uninjected...

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Literature Corpus work
219f0a3d-4318-55dd-a852-e512db6512d9
DOI
10.64898/2026.04.07.716986
Open publication

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Intratumoural oncolytic HSV-1 reshapes the local and systemic immune landscape through CD8 <sup>⁺</sup> T cell reprogrammingDOI 10.64898/2026.04.07.716986
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