Article

Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β

2024-01-20

Abstract excerpt

<h4>Summary</h4> Neuronal aging and neurodegenerative diseases are accompanied by proteostasis collapse, while the cellular factors that trigger it have not been identified. Impaired mitochondrial transport in the axon is another feature of aging and neurodegenerative diseases. Using Drosophila , we found that genetic depletion of axonal mitochondria causes dysregulation of protein degradation. Axons with mitoch...

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Literature Corpus work: be2c8fc3-0221-5fd0-a555-43f4888f5e65
DOI: 10.1101/2024.01.20.576435

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