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Article

TSG101 negatively regulates mitochondrial biogenesis in axons.

Proceedings of the National Academy of Sciences of the United States of America - 18 May 2021

Lin Tzu-Huai, Bis-Brewer Dana M, Sheehan Amy E, Townsend Louise N, Maddison Daniel C, Züchner Stephan, Smith Gaynor A, Freeman Marc R

Abstract excerpt

There is a tight association between mitochondrial dysfunction and neurodegenerative diseases and axons that are particularly vulnerable to degeneration, but how mitochondria are maintained in axons to support their physiology remains poorly defined. In an in vivo forward genetic screen for mutants altering axonal mitochondria, we identified tsg101 Neurons mutant for tsg101 exhibited an increase in mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33972422
DOI: 10.1073/pnas.2018770118
PMCID: PMC8157921

Genes

TSG101
PGC
TFEB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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