Article

eIF2α phosphorylation evokes dystonia-like movements with D2-receptor and cholinergic origin and abnormal neuronal connectivity

2024-05-15

Abstract excerpt

<h4>Summary</h4> Dystonia is the 3 rd most common movement disorder. Dystonia is acquired through either injury or genetic mutations, with poorly understood molecular and cellular mechanisms. Eukaryotic initiation factor alpha (eIF2α) controls cell state including neuronal plasticity via protein translation control and expression of ATF4. Dysregulated eIF2α phosphorylation (eIF2α-P) occurs in dystonia patients a...

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Literature Corpus work: 3910ab06-d83d-5314-b13f-111b2981f298
DOI: 10.1101/2024.05.14.594240

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