Article

Soma-centered control of synaptic autophagy by Rab39-regulated anterograde trafficking of Atg9

2024-11-21

Abstract excerpt

Presynaptic terminals can be located far from the neuronal cell body and are thought to independently regulate protein and organelle turnover. In this work, we report a soma-centered mechanism that regulates autophagy-driven protein turnover at distant presynaptic terminals in Drosophila . We show that this system is regulated by Rab39, whose human homolog is mutated in Parkinson’s disease. Although Rab39 is loca...

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Literature Corpus work: 5069db6f-354e-530f-b8cf-0e92f5d1b41c
DOI: 10.1101/2024.11.21.624639

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