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In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging

7 Aug 2017

Abstract excerpt

Mitophagy is thought to be a critical mitochondrial quality control mechanism in neurons and has been extensively studied in neurological disorders such as Parkinson's disease. However, little is known about how mitochondria are maintained in the lengthy neuronal axons in the context of physiological aging. Here, we utilized the unique Drosophila wing nerve model and in vivo imaging to rigorously profile changes...

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PMID: 28782874
DOI: 10.1111/acel.12654

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