Article
Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles.
PloS one - 1 Jan 2016
Ratliff Eric P, Kotzebue Roxanne W, Molina Brandon, Mauntz Ruth E, Gonzalez Arysa, Barekat Ayeh, El-Mecharrafie Nadja, Garza Shannon, Gurney Michael A, Achal Madhulika, Linton Phyllis-Jean, Harris Greg L, Finley Kim D
Abstract excerpt
The autophagy pathway is critical for the long-term homeostasis of cells and adult organisms and is often activated during periods of stress. Reduced pathway efficacy plays a central role in several progressive neurological disorders that are associated with the accumulation of cytotoxic peptides and protein aggregates. Previous studies have shown that genetic and transgenic alterations to the autophagy pathway...
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