Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagy

26 Apr 2022

Abstract excerpt

Mitostasis, the process of mitochondrial maintenance by biogenesis and degradative mechanisms, is challenged by the extreme length of axons. PINK1 (PTEN induced putative kinase 1) is a mitochondrial protein that targets damaged mitochondria for mitophagy. In reconciling the short half-life of PINK1 with the need for mitophagy of damaged axonal mitochondria, we found that axonal mitophagy depends on local...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Mitochondrial Function and Pathology
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35470750
DOI: 10.1080/15548627.2022.2070332

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondrial hitch-hiking of Pink1 mRNA supports axonal mitophagyPMID 35470750Read ↗

PINK1- and PARK2-mediated local mitophagy in distal neuronal axons.Semantic proximity Read ↗

Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?Semantic proximity Read ↗

Mechanisms of neurodegeneration in Parkinson’s disease: keep neurons in the PINK1Semantic proximity Read ↗

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gateSemantic proximity Read ↗

In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal agingSemantic proximity Read ↗

Mitochondrial protein import regulates cytosolic protein homeostasis and neuronal integrity.Semantic proximity Read ↗

Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons.Semantic proximity Read ↗

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical NeuronsSemantic proximity Read ↗

Discovery and implications of transcellular mitophagySemantic proximity Read ↗

Misregulation of mitochondria-lysosome contact dynamics in Charcot-Marie-Tooth Type 2B disease Rab7 mutant sensory peripheral neurons.Semantic proximity Read ↗

Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions.Semantic proximity Read ↗

Loss of neuronal Miro1 disrupts mitophagy and induces hyperactivation of the integrated stress responseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.