Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients.

doi:10.1073/pnas.2119483119

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Article

Altered CXCR4 dynamics at the cell membrane impairs directed cell migration in WHIM syndrome patients.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 2022

García-Cuesta Eva M, Rodríguez-Frade José Miguel, Gardeta Sofía R, D'Agostino Gianluca, Martínez Pablo, Soler Palacios Blanca, Cascio Graciela, Wolf Tobias, Mateos Nicolas, Ayala-Bueno Rosa, Santiago César A, Lucas Pilar, Llorente Lucia, Allende Luis M, González-Granado Luis Ignacio, Martín-Cófreces Noa, Roda-Navarro Pedro, Sallusto Federica, Sánchez-Madrid Francisco, García-Parajo María F, Martínez-Muñoz Laura, Mellado Mario

Abstract excerpt

Chemokine receptor nanoscale organization at the cell membrane is orchestrated by the actin cytoskeleton and influences cell responses. Using single-particle tracking analysis we show that CXCR4R334X, a truncated mutant chemokine receptor linked to WHIM syndrome (warts, hypogammaglobulinemia, infections, myelokathexis), fails to nanoclusterize after CXCL12 stimulation, and alters the lateral mobility and spatial...

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Identifiers

PMID: 35588454
DOI: 10.1073/pnas.2119483119
PMCID: PMC9173760

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