Article
Cell-intrinsic activation of Orai1 regulates human T cell motility
2017-04-19
Abstract excerpt
Ca 2+ signaling through the store-operated Ca 2+ channel, Orai1, is crucial for T cell function, but a role in regulating T cell motility in lymph nodes has not been previously reported. Tracking human T cells in immunodeficient mouse lymph nodes and in microfabricated PDMS channels, we show that inhibition of Orai1 channel activity with a dominant-negative Orai1-E106A construct increases average T cell velociti...
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Identifiers and source
- Literature Corpus work
- 957f7f7a-a786-5e20-9de5-6cf5ee53d2bc
- DOI
- 10.1101/128595