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Article

Primary immunodeficiencies due to abnormalities of the actin cytoskeleton

5 Oct 2016

Abstract excerpt

PURPOSE OF REVIEW: Primary immunodeficiencies (PIDs) are inherited conditions where components of the immune system are missing or dysfunctional. Over 300 genes have been causally linked to monogenic forms of PID, including a number that regulate the actin cytoskeleton. The majority of cytoskeletal defects disrupt assembly and disassembly of filamentous actin in multiple immune cell lineages impacting functions...

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PMID: 27749373
DOI: 10.1097/moh.0000000000000296

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