Article
Epidermal cells are the primary phagocytes in the fragmentation and clearance of degenerating dendrites in Drosophila.
Neuron - 5 Feb 2014
Han Chun, Song Yuanquan, Xiao Hui, Wang Denan, Franc Nathalie C, Jan Lily Yeh, Jan Yuh-Nung
Abstract excerpt
During developmental remodeling, neurites destined for pruning often degenerate on-site. Physical injury also induces degeneration of neurites distal to the injury site. Prompt clearance of degenerating neurites is important for maintaining tissue homeostasis and preventing inflammatory responses. Here we show that in both dendrite pruning and dendrite injury of Drosophila sensory neurons, epidermal cells rather...
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