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Glial Phagocytic Receptors Promote Neuronal Loss in Adult Drosophila Brain

1 Nov 2019

Abstract excerpt

Glial phagocytosis is critical for the development and maintenance of the CNS in vertebrates and flies and relies on the function of phagocytic receptors to remove apoptotic cells and debris. Glial phagocytic ability declines with age, which correlates with neuronal dysfunction, suggesting that increased glial phagocytosis may prevent neurodegeneration. Contradicting this hypothesis, we provide experimental...

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PMID: 31693886
DOI: 10.1016/j.celrep.2019.09.086

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