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Article

A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis

24 Dec 2022

Abstract excerpt

Phagocytic clearance of dying cells, termed efferocytosis, is essential for maintaining tissue homeostasis, yet our understanding of efferocytosis regulation remains incomplete. Here we perform a FACS-based, genome-wide CRISPR knockout screen in primary mouse macrophages to search for novel regulators of efferocytosis. The results show that Wdfy3 knockout in macrophages specifically impairs uptake, but not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36566259
DOI: 10.1038/s41467-022-35604-8

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