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<i>Drosophila p53</i> isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control

2020-07-22

Abstract excerpt

p53 gene family members in humans and other organisms encode a large number of protein isoforms whose functions are largely undefined. Using Drosophila as a model, we find that a p53B isoform is expressed predominantly in the germline where it colocalizes with p53A into subnuclear bodies. It is only p53A, however, that mediates the apoptotic response to ionizing radiation in the germline and soma. In contrast, p5...

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Identifiers and source

Literature Corpus work
bdce03cd-1879-5668-ab04-084d5989013c
DOI
10.1101/2020.07.21.214692
Open publication

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<i>Drosophila p53</i> isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality controlDOI 10.1101/2020.07.21.214692
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