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Article

DNA damage responses and p53 in the aging process

15 Nov 2017

Abstract excerpt

Abstract The genome is constantly attacked by genotoxic insults. DNA damage has long been established as a cause of cancer development through its mutagenic consequences. Conversely, radiation therapy and chemotherapy induce DNA damage to drive cells into apoptosis or senescence as outcomes of the DNA damage response (DDR). More recently, DNA damage has been recognized as a causal factor for the aging process....

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PMID: 29141944
DOI: 10.1182/blood-2017-07-746396

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