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Control mechanisms in germ cells mediated by p53 family proteins

10 Aug 2017

Abstract excerpt

Germ cells are totipotent and, in principle, immortal as they are the source for new germ cells in each generation. This very special role requires tight quality control systems. The p53 protein family constitutes one of the most important quality surveillance systems in cells. Whereas p53 has become famous for its role as the guardian of the genome in its function as the most important somatic tumor suppressor,...

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PMID: 28794013
DOI: 10.1242/jcs.204859

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