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Article

p53-independent apoptosis limits DNA damage-induced aneuploidy.

Genetics - 1 Jun 2009

McNamee Laura M, Brodsky Michael H

Abstract excerpt

DNA damage or unprotected telomeres can trigger apoptosis via signaling pathways that directly sense abnormal DNA structures and activate the p53 transcription factor. We describe a p53-independent mechanism that acts in parallel to the canonical DNA damage response pathway in Drosophila to induce apoptosis after exposure to ionizing radiation. Following recovery from damage-induced cell cycle arrest, p53 mutant...

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Identifiers

PMID: 19364807
DOI: 10.1534/genetics.109.102327
PMCID: PMC2691752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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