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Drosophila p53 directs nonapoptotic programs in postmitotic tissue

20 Mar 2019

Abstract excerpt

TP53 is the most frequently mutated gene in human cancers, and despite intensive research efforts, genome-scale studies of p53 function in whole animal models are rare. The need for such in vivo studies is underscored by recent challenges to established paradigms, indicating that unappreciated p53 functions contribute to cancer prevention. Here we leveraged the Drosophila system to interrogate p53 function in a...

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PMID: 30892991
DOI: 10.1091/mbc.e18-12-0791

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