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Polygenic risk score (PRS) and its potential for breast cancer risk stratification.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 1 Jan 2023

Hovhannisyan M, Kleiblová P, Nehasil P, Soukupová J, Zemánková P, Kleibl Z, Janatová M

Abstract excerpt

BACKGROUND: Breast cancer is a complex, multifactorial disease influenced by many genetic factors. Besides the relatively rare pathogenic variants in high or moderate penetrant cancer predisposition genes, breast cancer risk is modified by numerous low risk alleles considered to be polygenic genetic factors. While the risks associated with individual polygenic loci are negligible, its cumulative effect can reach...

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PMID: 37353348
DOI: 10.48095/ccko2023198

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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