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Small-molecule inhibition of the <i>Orientia tsutsugamushi</i> deubiquitylating enzyme OtDUB impairs bacterial reproduction

2026-06-26

Abstract excerpt

Scrub typhus is a potentially fatal infectious disease caused by the obligate intracellular bacterium Orientia tsutsugamushi . While antibiotic treatment is generally effective, it requires extended treatment, and drug resistance and treatment failures have emerged. O. tsutsugamushi encodes a deubiquitylating enzyme, OtDUB, which interferes with host ubiquitin-dependent pathways. OtDUB cleaves ubiquitin from var...

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Literature Corpus work
d12797a8-91e7-5a82-8a35-74d800f9744a
DOI
10.64898/2026.06.25.734012
Open publication

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Small-molecule inhibition of the <i>Orientia tsutsugamushi</i> deubiquitylating enzyme OtDUB impairs bacterial reproductionDOI 10.64898/2026.06.25.734012
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