Article

Typhoid toxin of <i>Salmonella enterica</i> induces ISG15 response mediating host cell survival and bacterial dissemination

2025-04-29

Abstract excerpt

The typhoid toxin is a secreted virulence factor of typhoidal serovars of the bacterial pathogen Salmonella enterica implicated in typhoid fever and chronic infections. The toxin causes a DNA damage response in human cells, characterised by cell-cycle arrest and cellular distension, resulting in cellular senescence and increased bacterial burden. To better understand host responses to typhoid toxin, we performed...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1a9e2ba1-a16a-55a5-8130-38d77b25c604
DOI: 10.1101/2025.04.29.649991

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Typhoid toxin of <i>Salmonella enterica</i> induces ISG15 response mediating host cell survival and bacterial disseminationDOI 10.1101/2025.04.29.649991Read

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype.Semantic proximity Read

Identification of A Putative T6SS Immunity Islet in Salmonella TyphiSemantic proximity Read

A genome-wide RNAi screen identifies host cell cycle regulation as a determinant of <i>Orientia tsutsugamushi</i> infectionSemantic proximity Read

The role of IFN-γ in cell-autonomous immune responses against Salmonella Typhimurium and Toxoplasma gondiiSemantic proximity Read

Salmonella Typhi Colonization Provokes Extensive Transcriptional Changes Aimed at Evading Host Mucosal Immune Defense During Early Infection of Human Intestinal TissueSemantic proximity Read

Dual RNA sequencing reveals dendritic cell reprogramming in response to typhoidal Salmonella invasion.Semantic proximity Read

Salmonella enterica Serovar Typhi and the Pathogenesis of Typhoid FeverSemantic proximity Read

Comparative transcriptional profiling of the early host response to infection by typhoidal and non-typhoidal Salmonella serovars in human intestinal organoidsSemantic proximity Read

The unique lipopolysaccharide composition of <i>Salmonella</i> Typhimurium ST313 dampens pyroptosis and inflammasome activation and suppresses host cell deathSemantic proximity Read

Streptococcus pneumoniae autolysin LytA inhibits ISG15 and ISGylation through decreasing bacterial DNA abnormally accumulated in the cytoplasm of macrophages.Semantic proximity Read

Impaired acid stress resistance in <i>Salmonella</i> Typhi Ty2Semantic proximity Read

Comparison of Salmonella enterica Serovars Typhi and Typhimurium Reveals Typhoidal Serovar-Specific Responses to BileSemantic proximity Read