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Article

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease.

International journal of molecular sciences - 28 Jan 2022

Suzuki Mari, Sango Kazunori, Nagai Yoshitaka

Abstract excerpt

α-Synuclein (αSyn) plays a major role in the pathogenesis of Parkinson's disease (PD), which is the second most common neurodegenerative disease after Alzheimer's disease. The accumulation of αSyn is a pathological hallmark of PD, and mutations in the SNCA gene encoding αSyn cause familial forms of PD. Moreover, the ectopic expression of αSyn has been demonstrated to mimic several key aspects of PD in...

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Identifiers

PMID: 35163450
DOI: 10.3390/ijms23031519
PMCID: PMC8835920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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