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Article

Intestine-derived α-synuclein initiates and aggravates pathogenesis of Parkinson’s disease in Drosophila

17 Oct 2022

Abstract excerpt

BACKGROUND: Aberrant aggregation of α-synuclein (α-syn) is a key pathological feature of Parkinson's disease (PD), but the precise role of intestinal α-syn in the progression of PD is unclear. In a number of genetic Drosophila models of PD, α-syn was frequently ectopically expressed in the neural system to investigate the pathobiology. METHOD: We investigated the potential role of intestinal α-syn in PD...

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PMID: 36253844
DOI: 10.1186/s40035-022-00318-w

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