Article

Evaluating transportability of <i>in-vitro</i> cellular models to <i>in-vivo</i> human phenotypes using gene perturbation data

2024-10-17

Abstract excerpt

Gene perturbation screens (e.g. CRISPR-Cas9) assess the impact of gene disruption on in-vitro cellular phenotypes (e.g., proliferation, anti-viral response, transcriptomics). In-vitro experiments can be useful models for understanding the aetiology of in-vivo (organismal) phenotypes. For example, anti-viral response in immune cells and infectious disease outcomes. However, assessing whether an in-vitro cellula...

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Literature Corpus work: 108f9a6a-7d27-5d2e-a7d1-4087119e6903
DOI: 10.1101/2024.10.17.618648

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