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Article

Targeting the Most Upstream Site of Wnt Signaling Pathway Provides a Strategic Advantage for Therapy in Colorectal Cancer

1 Jul 2008

Abstract excerpt

The Wnt signaling pathway has important functions in development, tissue homeostasis, and regeneration. Deregulation of canonical Wnt/beta-catenin signaling is frequently found in various human cancers, particularly in colorectal cancer, and non-canonical Wnt signaling pathways also have been implicated in neoplasia. Colorectal cancer is a multi-pathway disease. Activation of Wnt signaling by both genetic and...

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PMID: 18673240
DOI: 10.2174/138945008784911769

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