Article

Joint inference of mutational signatures from indels and single-nucleotide substitutions reveals prognostic impact of homologous recombination deficiency in tumors

2024-08-21

Abstract excerpt

<title>Abstract</title> <p>Mutational signatures are increasingly used to understand the mechanisms causing cancer, predict prognosis and stratify patients for therapy. However, inference of mutational signatures can be error-prone, particularly in the case of featureless, low-sparsity signatures, which often get confounded. One of them is the homologous recombination deficiency-associated signature SBS3, relevan...

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Literature Corpus work: 97288275-7644-5ad0-8b8e-9a9dd61dd267
DOI: 10.21203/rs.3.rs-4833999/v1

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