Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PMAT variant rs3889348 is associated with metformin-induced gastrointestinal among Chinese Type 2 diabetes patients.

Pharmacogenomics - 1 Jul 2023

Liu Ziqing, Jia Xiao, Wu Peng, Wu Benrui, Pan Ying, Zhong Shao, Xiao Luhua, Song Yuehong, Hu Jinbo, Zhou Kaixin

Abstract excerpt

Aim: This study examined intronic gene variants for their association with metformin intolerance in a Chinese population, focusing on the plasma monoamine transporter (PMAT) cis-protein expression quantitative trait loci (cis-eQTL) variant rs3889348. Methods: We recruited Type 2 diabetes patients from two hospitals and identified 111 metformin-intolerant patients using a questionnaire, and selected 206...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to East Asian People

Share to Gastrointestinal Diseases

Share to Hypoglycemic Agents

Share to Metformin

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 37458617
DOI: 10.2217/pgs-2023-0078

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PMAT variant rs3889348 is associated with metformin-induced gastrointestinal among Chinese Type 2 diabetes patients.PMID 37458617Read ↗

Variation in the plasma membrane monoamine transporter (PMAT, encoded in <i>SLC29A4</i> ) and organic cation transporter 1 (OCT1, encoded in <i>SLC22A1</i> ) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT studySemantic proximity Read ↗

Organic cation transporter 1 variants and gastrointestinal side effects of metformin in patients with Type 2 diabetes.Semantic proximity Read ↗

Association between organic cation transporter genetic polymorphisms and metformin response and intolerance in T2DM individuals: a systematic review and meta-analysis.Semantic proximity Read ↗

Implications of genetic variations, differential gene expression, and allele-specific expression on metformin response in drug-naïve type 2 diabetes.Semantic proximity Read ↗

A Review of the Impact of Pharmacogenetics and Metabolomics on the Efficacy of Metformin in Type 2 DiabetesSemantic proximity Read ↗

Influence of GLUT2 rs8192675, MATE1 rs2289669, and OCT2 rs316019 Genetic Polymorphism on Metformin Efficacy and Glycemic Control in Type 2 Diabetes Mellitus PatientsSemantic proximity Read ↗

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.Semantic proximity Read ↗

Genetic Polymorphism in the Organic Cation Transporters 1 (OCT1) Gene and its Effect on Therapeutic Efficacy and Gastrointestinal Side Effects of Metformin in Patients with Type 2 Diabetes Mellitus in Basrah/ Southern Iraq.Semantic proximity Read ↗

Identification of Novel Intronic SNPs in Transporter Genes Associated with Metformin Side Effects.Semantic proximity Read ↗

Pharmacogenetic variation and metformin response.Semantic proximity Read ↗

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.Semantic proximity Read ↗

Effects of single-nucleotide polymorphism on the pharmacokinetics and pharmacodynamics of metformin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.